During his weekly appearance on the "Dale & Holly Show" on Boston sports radio station WEEI, New England Patriots nose tackle Vince Wilfork discussed the NFL's proposed 18-game "enhanced" regular season. "Well, that's going to be a big problem, because if you want to pay us like pre-season, it won’t work. But if you're going to take those two (pre-season games) and make it into a regular season game, we'll the pay has to be different, that’s point blank," Wilfork said. "Me personally, a fan of football, I care less about 18-, 20-game season, as long as the pay is right. Don’t pay me as four preseason games when it’s only two preseason games, and the other two is regular-season games. So if you want it like that, well, you have to come out of your pockets for it. It won’t work if you put an 18-game season together and expect guys to play for two games for pre-season salary. It would not work. It would be a big problem." Wilfork signed a five-year, $40 million contract, with $18 million in guarantees, in early March. Source: Mac's Football Blog
You would have to increase the size of the teams from 53 to approximately 60 to cover the additional injuries. I think 16 is plenty of games.