Lots of injuries this week you need to keep an eye on: Griffen, Burfict, Foster, Travathan, Ansah, Pullard, Timmons (Out) and Vaccaro. I'd have Vaccaro ranked higher if not for his groin injury, if he suits up I think he has a great matchup against the run heavy Bills.
| Rank | Player | Team | Pos | Opp |
| 1 | Luke Kuechly | CAR | LB1 | vs. MIA |
| 2 | Bobby Wagner | SEA | LB2 | at ARI |
| 3 | Joey Bosa | LAC | DE1 | at JAC |
| 4 | Ryan Shazier | PIT | LB3 | at IND |
| 5 | Telvin Smith | JAC | LB4 | vs. LAC |
| 6 | Landon Collins | NYG | S1 | at SF |
| 7 | Kwon Alexander | TB | LB5 | vs. NYJ |
| 8 | Reshad Jones | MIA | S2 | at CAR |
| 9 | Jason Pierre-Paul | NYG | DE2 | at SF |
| 10 | Cameron Jordan | NO | DE3 | at BUF |
| 11 | Alec Ogletree | LAR | LB6 | vs. HOU |
| 12 | Zach Brown | WAS | LB7 | vs. MIN |
| 13 | Everson Griffen (Q) | MIN | DE4 | at WAS |
| 14 | Calais Campbell | JAC | DE5 | vs. LAC |
| 15 | Vontaze Burfict (Q) | CIN | LB8 | at TEN |
| 16 | Melvin Ingram | LAC | DE6 | at JAC |
| 17 | Blake Martinez | GB | LB9 | at CHI |
| 18 | Aaron Donald | LAR | DT1 | vs. HOU |
| 19 | Deion Jones | ATL | LB10 | vs. DAL |
| 20 | Demarcus Lawrence | DAL | DE7 | at ATL |
| 21 | Sean Lee | DAL | LB11 | at ATL |
| 22 | Keanu Neal | ATL | S3 | vs. DAL |
| 23 | Trey Flowers | NE | DE8 | at DEN |
| 24 | Reuben Foster (Q) | SF | LB12 | vs. NYG |
| 25 | Carlos Dunlap | CIN | DE9 | at TEN |
| 26 | Christian Kirksey | CLE | LB13 | at DET |
| 27 | Jarrad Davis | DET | LB14 | vs. CLE |
| 28 | Mark Barron | LAR | LB15 | vs. HOU |
| 29 | Tyvon Branch | ARI | S4 | vs. SEA |
| 30 | DeForest Buckner | SF | DE10 | vs. NYG |
| 31 | Myles Garrett | CLE | DE11 | at DET |
| 32 | Myles Jack | JAC | LB16 | vs. LAC |
| 33 | Harrison Smith | MIN | S5 | at WAS |
| 34 | Danielle Hunter | MIN | DE12 | at WAS |
| 35 | Jamie Collins | CLE | LB17 | at DET |
| 36 | Wesley Woodyard | TEN | LB18 | vs. CIN |
| 37 | Eric Kendricks | MIN | LB19 | at WAS |
| 38 | Michael Bennett | SEA | DE13 | at ARI |
| 39 | Deone Bucannon | ARI | LB20 | vs. SEA |
| 40 | Demario Davis | NYJ | LB21 | at TB |
| 41 | Benardrick McKinney | HOU | LB22 | at LAR |
| 42 | Lavonte David | TB | LB23 | vs. NYJ |
| 43 | David Irving | DAL | DT2 | at ATL |
| 44 | Danny Trevathan (Q) | CHI | LB24 | vs. GB |
| 45 | Kevin Byard | TEN | S6 | vs. CIN |
| 46 | Ezekiel Ansah (Q) | DET | DE14 | vs. CLE |
| 47 | Hayes Pullard (Q) | LAC | LB25 | at JAC |
| 48 | Nick Vigil | CIN | LB26 | at TEN |
| 49 | Barry Church | JAC | S7 | vs. LAC |
| 50 | Frank Clark | SEA | DE15 | at ARI |
| 51 | Von Miller | DEN | LB27 | vs. NE |
| 52 | Ndamukong Suh | MIA | DT3 | at CAR |
| 53 | Glover Quin | DET | S8 | vs. CLE |
| 54 | K.J. Wright | SEA | LB28 | at ARI |
| 55 | Adrian Amos | CHI | S9 | vs. GB |
| 56 | Kurt Coleman | CAR | S10 | vs. MIA |
| 57 | Hasean Clinton-Dix | GB | S11 | at CHI |
| 58 | Craig Robertson | NO | LB29 | at BUF |
| 59 | Kenny Vaccaro (Q) | NO | S12 | at BUF |
| 60 | Kiko Alonso | MIA | LB31 | at CAR |
| 61 | Tahir Whitehead | DET | LB32 | vs. CLE |
| 62 | Tavon Wilson | DET | S13 | vs. CLE |
| 63 | Darron Lee | NYJ | LB33 | at TB |
| 64 | Eric Reid | SF | S14 | vs. NYG |
| 65 | Thomas Davis | CAR | LB34 | vs. MIA |
| 66 | Jahleel Addae | LAC | S15 | at JAC |
