| Rank | Player | Pos | Team | Opp |
| 1 | Bobby Wagner | LB1 | SEA | at JAC |
| 2 | Joey Bosa | DE1 | LAC | vs. WAS |
| 3 | Luke Kuechly | LB2 | CAR | vs. MIN |
| 4 | Zach Brown | LB3 | WAS | at LAC |
| 5 | Calais Campbell | DE2 | JAC | vs. SEA |
| 6 | C.J. Mosley | LB4 | BAL | at PIT |
| 7 | Blake Martinez | LB5 | GB | at CLE |
| 8 | Demarcus Lawrence | DE3 | DAL | at NYG |
| 9 | Everson Griffen | DE4 | MIN | at CAR |
| 10 | Melvin Ingram | DE5 | LAC | vs. WAS |
| 11 | Telvin Smith | LB6 | JAC | vs. SEA |
| 12 | Landon Collins | S1 | NYG | vs. DAL |
| 13 | Reshad Jones | S2 | MIA | vs. NE |
| 14 | Cameron Jordan | DE6 | NO | at ATL |
| 15 | Brandon Graham | DE7 | PHI | at LAR |
| 16 | Jason Pierre-Paul | DE8 | NYG | vs. DAL |
| 17 | Deion Jones | LB7 | ATL | vs. NO |
| 18 | Khalil Mack | DE9 | OAK | at KC |
| 19 | Keanu Neal | S3 | ATL | vs. NO |
| 20 | Danielle Hunter | DE10 | MIN | at CAR |
| 21 | Vontaze Burfict | LB8 | CIN | vs. CHI |
| 22 | Wesley Woodyard | LB9 | TEN | at ARI |
| 23 | Joe Schobert | LB10 | CLE | vs. GB |
| 24 | Jordan Poyer | S4 | BUF | vs. IND |
| 25 | Demario Davis | LB11 | NYJ | at DEN |
| 26 | Aaron Donald | DT1 | LAR | vs. PHI |
| 27 | Yannick Ngakoue | DE11 | JAC | vs. SEA |
| 28 | Danny Trevathan | LB12 | CHI | at CIN |
| 29 | Harrison Smith | S5 | MIN | at CAR |
| 30 | Myles Garrett | DE12 | CLE | vs. GB |
| 31 | Sean Lee | LB13 | DAL | at NYG |
| 32 | Kwon Alexander | LB14 | TB | vs. DET |
| 33 | Morgan Burnett | S6 | GB | at CLE |
| 34 | Trey Flowers | DE13 | NE | at MIA |
| 35 | Akiem Hicks | DT2 | CHI | at CIN |
| 36 | Carlos Dunlap | DE14 | CIN | vs. CHI |
| 37 | Reuben Foster | LB15 | SF | at HOU |
| 38 | Budda Baker | S7 | ARI | vs. TEN |
| 39 | Mark Barron | LB16 | LAR | vs. PHI |
| 40 | Alec Ogletree | LB17 | LAR | vs. PHI |
| 41 | David Irving | DT3 | DAL | at NYG |
| 42 | DeForest Buckner | DE15 | SF | at HOU |
| 43 | Christian Kirksey | LB18 | CLE | vs. GB |
| 44 | Benardrick McKinney | LB19 | HOU | vs. SF |
| 45 | Karl Joseph | S8 | OAK | at KC |
| 46 | Tahir Whitehead | LB20 | DET | at TB |
| 47 | Cameron Heyward | DE16 | PIT | vs. BAL |
| 48 | Navorro Bowman | LB21 | OAK | at KC |
| 49 | Eric Reid | S9 | SF | at HOU |
| 50 | Anthony Zettel | DT4 | DET | at TB |
| 51 | Michael Bennett | DE17 | SEA | at JAC |
| 52 | Barry Church | S10 | JAC | vs. SEA |
| 53 | Olivier Vernon | DE18 | NYG | vs. DAL |
| 54 | Jon Bostic | LB22 | IND | at BUF |
| 55 | K.J. Wright | LB23 | SEA | at JAC |
| 56 | Preston Brown | LB24 | BUF | vs. IND |
| 57 | Lavonte David | LB25 | TB | vs. DET |
| 58 | Kiko Alonso | LB26 | MIA | vs. NE |
| 59 | Cameron Wake | DE19 | MIA | vs. NE |
| 60 | Kurt Coleman | S11 | CAR | vs. MIN |
