| Rank | Player | Team | Pos | Opp |
| 1 | Cory Littleton | LAR | LB | vs. SEA |
| 2 | Bobby Wagner | SEA | LB | at LAR |
| 3 | Darius Leonard | IND | LB | at TB |
| 4 | Joe Schobert | CLE | LB | vs. CIN |
| 5 | Blake Martinez | GB | LB | vs. WAS |
| 6 | Devin White | TB | LB | vs. IND |
| 7 | Jordan Hicks | ARI | LB | vs. PIT |
| 8 | Fred Warner | SF | LB | at NO |
| 9 | Jaylon Smith | DAL | LB | at CHI |
| 10 | Eric Reid | CAR | S | at ATL |
| 11 | Roquan Smith | CHI | LB | vs. DAL |
| 12 | Demario Davis | NO | LB | vs. SF |
| 13 | T.J. Watt | PIT | LB | at ARI |
| 14 | Cameron Heyward | PIT | DE | at ARI |
| 15 | Luke Kuechly | CAR | LB | at ATL |
| 16 | Aaron Donald | LAR | DT | vs. SEA |
| 17 | Zach Cunningham | HOU | LB | vs. DEN |
| 18 | Budda Baker | ARI | S | vs. PIT |
| 19 | Jayon Brown | TEN | LB | at OAK |
| 20 | Landon Collins | WAS | S | at GB |
| 21 | Joey Bosa | LAC | DE | at JAC |
| 22 | Shaq Thompson | CAR | LB | at ATL |
| 23 | Vonn Bell | NO | S | vs. SF |
| 24 | Danielle Hunter | MIN | DE | vs. DET |
| 25 | Cameron Jordan | NO | DE | vs. SF |
| 26 | Lavonte David | TB | LB | vs. IND |
| 27 | Deion Jones | ATL | LB | vs. CAR |
| 28 | Logan Ryan | TEN | CB | at OAK |
| 29 | Jordan Poyer | BUF | S | vs. BAL |
| 30 | A.J. Johnson | DEN | LB | at HOU |
| 31 | Nick Bosa | SF | DE | at NO |
| 32 | Brandon Graham | PHI | DE | vs. NYG |
| 33 | Tremaine Edmunds | BUF | LB | vs. BAL |
| 34 | Jamal Adams | NYJ | S | vs. MIA |
| 35 | Todd Davis | DEN | LB | at HOU |
| 36 | Matt Milano | BUF | LB | vs. BAL |
| 37 | Calais Campbell | JAC | DE | vs. LAC |
| 38 | De'Vondre Campbell | ATL | LB | vs. CAR |
| 39 | Justin Houston | IND | DE | at TB |
| 40 | DeForest Buckner | SF | DT | at NO |
| 41 | Melvin Ingram | LAC | DE | at JAC |
| 42 | Devin Bush | PIT | LB | at ARI |
| 43 | Nick Vigil | CIN | LB | at CLE |
| 44 | Shawn Williams | CIN | S | at CLE |
| 45 | Rashaan Evans | TEN | LB | at OAK |
| 46 | Harrison Smith | MIN | S | vs. DET |
| 47 | Jessie Bates III | CIN | S | at CLE |
| 48 | Maxx Crosby | OAK | DE | vs. TEN |
| 49 | Khalil Mack | CHI | LB | vs. DAL |
| 50 | Jamie Collins | NE | LB | vs. KC |
| 51 | Eric Kendricks | MIN | LB | vs. DET |
| 52 | Taylor Rapp | LAR | S | vs. SEA |
| 53 | Yannick Ngakoue | JAC | DE | vs. LAC |
| 54 | K.J. Wright | SEA | LB | at LAR |
| 55 | Sean Lee | DAL | LB | at CHI |
| 56 | Demarcus Lawrence | DAL | DE | at CHI |
| 57 | Thomas Davis | LAC | LB | at JAC |
| 58 | Jason Pierre-Paul | TB | DE | vs. IND |
| 59 | Jonathan Allen | WAS | DE | at GB |
| 60 | Jerome Baker | MIA | LB | at NYJ |
| 61 | Arik Armstead | SF | DE | at NO |
| 62 | Justin Simmons | DEN | S | at HOU |
| 63 | Kyle Fuller | CHI | CB | vs. DAL |
| 64 | Dre Greenlaw | SF | LB | at NO |
| 65 | Robert Quinn | DAL | DE | at CHI |
| 66 | Neville Hewitt | NYJ | LB | vs. MIA |
| 67 | Minkah Fitzpatrick | PIT | S | at ARI |
| 68 | Sam Hubbard | CIN | DE | at CLE |
| 69 | James Burgess | NYJ | LB | vs. MIA |
| 70 | Drue Tranquill | LAC | LB | at JAC |
