| Rank | Player | Team | Opp |
| 1 | Darius Leonard | IND | vs. NYG |
| 2 | Blake Martinez | GB | at NYJ |
| 3 | Luke Kuechly | CAR | vs. ATL |
| 4 | Derwin James | LAC | vs. BAL |
| 5 | Jamal Adams | NYJ | vs. GB |
| 6 | Bobby Wagner | SEA | vs. KC |
| 7 | Roquan Smith | CHI | at SF |
| 8 | Kiko Alonso | MIA | vs. JAC |
| 9 | Telvin Smith | JAC | at MIA |
| 10 | Danielle Hunter | MIN | at DET |
| 11 | Lavonte David | TB | at DAL |
| 12 | Tremaine Edmunds | BUF | at NE |
| 13 | C.J. Mosley | BAL | at LAC |
| 14 | Cory Littleton | LAR | at ARI |
| 15 | J.J. Watt | HOU | at PHI |
| 16 | Budda Baker | ARI | vs. LAR |
| 17 | Khalil Mack | CHI | at SF |
| 18 | Myles Garrett | CLE | vs. CIN |
| 19 | Avery Williamson | NYJ | vs. GB |
| 20 | Aaron Donald | LAR | at ARI |
| 21 | Chandler Jones | ARI | vs. LAR |
| 22 | Antoine Bethea | ARI | vs. LAR |
| 23 | Harrison Smith | MIN | at DET |
| 24 | Alec Ogletree | NYG | at IND |
| 25 | Joey Bosa | LAC | vs. BAL |
| 26 | Fred Warner | SF | vs. CHI |
| 27 | Calais Campbell | JAC | at MIA |
| 28 | Jessie Bates III | CIN | at CLE |
| 29 | Leighton Vander Esch | DAL | vs. TB |
| 30 | Danny Trevathan | CHI | at SF |
| 31 | Reshad Jones | MIA | vs. JAC |
| 32 | Tyrann Mathieu | HOU | at PHI |
| 33 | Jaylon Smith | DAL | vs. TB |
| 34 | Todd Davis | DEN | at OAK |
| 35 | Myles Jack | JAC | at MIA |
| 36 | Jason Pierre-Paul | TB | at DAL |
| 37 | Demarcus Lawrence | DAL | vs. TB |
| 38 | Cameron Jordan | NO | vs. PIT |
| 39 | Bradley McDougald | SEA | vs. KC |
| 40 | Shawn Williams | CIN | at CLE |
| 41 | Demario Davis | NO | vs. PIT |
| 42 | Hasean Clinton-Dix | WAS | at TEN |
| 43 | Tre Boston | ARI | vs. LAR |
| 44 | Anthony Hitchens | KC | at SEA |
| 45 | Bradley Chubb | DEN | at OAK |
| 46 | Kevin Byard | TEN | vs. WAS |
| 47 | Carlos Dunlap | CIN | at CLE |
| 48 | Chris Jones | KC | at SEA |
| 49 | Frank Clark | SEA | vs. KC |
| 50 | Anthony Walker | IND | vs. NYG |
