| Rank | Player | Team | Pos | Opp |
| 1 | Cory Littleton | LAR | LB | at SEA |
| 2 | Bobby Wagner | SEA | LB | vs. LAR |
| 3 | Luke Kuechly | CAR | LB | vs. JAC |
| 4 | Blake Martinez | GB | LB | at DAL |
| 5 | Leighton Vander Esch | DAL | LB | vs. GB |
| 6 | Jordan Hicks | ARI | LB | at CIN |
| 7 | Joe Schobert | CLE | LB | at SF |
| 8 | Deion Jones | ATL | LB | at HOU |
| 9 | John Johnson | LAR | S | at SEA |
| 10 | Landon Collins | WAS | S | vs. NE |
| 11 | Devin Bush | PIT | LB | vs. BAL |
| 12 | Jaylon Smith | DAL | LB | vs. GB |
| 13 | Tremaine Edmunds | BUF | LB | at TEN |
| 14 | Lavonte David | TB | LB | at NO |
| 15 | Zach Cunningham | HOU | LB | vs. ATL |
| 16 | Shaquil Barrett | TB | LB | at NO |
| 17 | Harrison Smith | MIN | S | at NYG |
| 18 | Danielle Hunter | MIN | DE | at NYG |
| 19 | Shaq Thompson | CAR | LB | vs. JAC |
| 20 | Budda Baker | ARI | S | at CIN |
| 21 | Joey Bosa | LAC | DE | vs. DEN |
| 22 | Vonn Bell | NO | S | vs. TB |
| 23 | Jordan Poyer | BUF | S | at TEN |
| 24 | Jamie Collins | NE | LB | at WAS |
| 25 | J.J. Watt | HOU | DE | vs. ATL |
| 26 | Thomas Davis | LAC | LB | vs. DEN |
| 27 | Danny Trevathan | CHI | LB | at OAK |
| 28 | Eric Kendricks | MIN | LB | at NYG |
| 29 | Khalil Mack | CHI | LB | at OAK |
| 30 | Myles Garrett | CLE | DE | at SF |
| 31 | Demario Davis | NO | LB | vs. TB |
| 32 | Jayon Brown | TEN | LB | vs. BUF |
| 33 | Aaron Donald | LAR | DT | at SEA |
| 34 | Shawn Williams | CIN | S | vs. ARI |
| 35 | Patrick Onwuasor | BAL | LB | at PIT |
| 36 | Ronnie Harrison | JAC | S | at CAR |
| 37 | Calais Campbell | JAC | DE | at CAR |
| 38 | Terrell Edmunds | PIT | S | vs. BAL |
| 39 | Antoine Bethea | NYG | S | vs. MIN |
| 40 | Anthony Walker | IND | LB | at KC |
| 41 | Matt Milano | BUF | LB | at TEN |
| 42 | Justin Reid | HOU | S | vs. ATL |
| 43 | Darnell Savage Jr. | GB | S | at DAL |
| 44 | Jabrill Peppers | NYG | S | vs. MIN |
| 45 | Anthony Hitchens | KC | LB | vs. IND |
| 46 | Quincy Williams | JAC | LB | at CAR |
| 47 | Cameron Jordan | NO | DE | vs. TB |
| 48 | Minkah Fitzpatrick | PIT | S | vs. BAL |
| 49 | Hasean Clinton-Dix | CHI | S | at OAK |
| 50 | Jessie Bates III | CIN | S | vs. ARI |
| 51 | Kyle Fuller | CHI | CB | at OAK |
| 52 | Whitney Mercilus | HOU | LB | vs. ATL |
| 53 | Kevin Byard | TEN | S | vs. BUF |
| 54 | Haason Reddick | ARI | LB | at CIN |
| 55 | Kendall Fuller | KC | CB | vs. IND |
| 56 | Sam Hubbard | CIN | DE | vs. ARI |
| 57 | Demarcus Lawrence | DAL | DE | vs. GB |
| 58 | Cameron Heyward | PIT | DE | vs. BAL |
| 59 | Todd Davis | DEN | LB | at LAC |
| 60 | Montae Nicholson | WAS | S | vs. NE |
| 61 | Jordan Whitehead | TB | S | at NO |
| 62 | Johnathan Joseph | HOU | CB | vs. ATL |
| 63 | Carlos Dunlap | CIN | DE | vs. ARI |
| 64 | Justin Simmons | DEN | S | at LAC |
| 65 | Anthony Harris | MIN | S | at NYG |
| 66 | Clayton Geathers | IND | S | at KC |
| 67 | Everson Griffen | MIN | DE | at NYG |
| 68 | Nick Vigil | CIN | LB | vs. ARI |
| 69 | Jadeveon Clowney | SEA | DE | vs. LAR |
| 70 | Chris Jones | KC | DT | vs. IND |
