| Rank | Player | Team | Pos | Opp |
| 1 | Cory Littleton | LAR | LB | at ATL |
| 2 | Blake Martinez | GB | LB | vs. OAK |
| 3 | Bobby Wagner | SEA | LB | vs. BAL |
| 4 | Jordan Hicks | ARI | LB | at NYG |
| 5 | Darius Leonard | IND | LB | vs. HOU |
| 6 | Leighton Vander Esch | DAL | LB | vs. PHI |
| 7 | Danielle Hunter | MIN | DE | at DET |
| 8 | Jamie Collins | NE | LB | at NYJ |
| 9 | Joey Bosa | LAC | DE | at TEN |
| 10 | Landon Collins | WAS | S | vs. SF |
| 11 | Deion Jones | ATL | LB | vs. LAR |
| 12 | Jaylon Smith | DAL | LB | vs. PHI |
| 13 | De'Vondre Campbell | ATL | LB | vs. LAR |
| 14 | Jamal Adams | NYJ | S | vs. NE |
| 15 | Nick Vigil | CIN | LB | vs. JAC |
| 16 | Jabrill Peppers | NYG | S | vs. ARI |
| 17 | Calais Campbell | JAC | DE | at CIN |
| 18 | J.J. Watt | HOU | DE | at IND |
| 19 | Eric Kendricks | MIN | LB | at DET |
| 20 | Tracy Walker | DET | S | vs. MIN |
| 21 | Cameron Jordan | NO | DE | at CHI |
| 22 | Vonn Bell | NO | S | at CHI |
| 23 | Demario Davis | NO | LB | at CHI |
| 24 | Shawn Williams | CIN | S | vs. JAC |
| 25 | Eric Weddle | LAR | S | at ATL |
| 26 | Jordan Poyer | BUF | S | vs. MIA |
| 27 | Harrison Smith | MIN | S | at DET |
| 28 | Budda Baker | ARI | S | at NYG |
| 29 | Nick Bosa | SF | DE | at WAS |
| 30 | Zach Cunningham | HOU | LB | at IND |
| 31 | DeForest Buckner | SF | DT | at WAS |
| 32 | Aaron Donald | LAR | DT | at ATL |
| 33 | Roquan Smith | CHI | LB | vs. NO |
| 34 | Haason Reddick | ARI | LB | at NYG |
| 35 | Rashaan Evans | TEN | LB | vs. LAC |
| 36 | Todd Davis | DEN | LB | vs. KC |
| 37 | Montae Nicholson | WAS | S | vs. SF |
| 38 | Demarcus Lawrence | DAL | DE | vs. PHI |
| 39 | Jadeveon Clowney | SEA | DE | vs. BAL |
| 40 | Antoine Bethea | NYG | S | vs. ARI |
| 41 | Justin Reid | HOU | S | at IND |
| 42 | Reshad Jones | MIA | S | at BUF |
| 43 | Everson Griffen | MIN | DE | at DET |
| 44 | Robert Quinn | DAL | DE | vs. PHI |
| 45 | Ronnie Harrison | JAC | S | at CIN |
| 46 | Fred Warner | SF | LB | at WAS |
| 47 | K.J. Wright | SEA | LB | vs. BAL |
| 48 | Myles Jack | JAC | LB | at CIN |
| 49 | Kevin Byard | TEN | S | vs. LAC |
| 50 | Justin Simmons | DEN | S | vs. KC |
| 51 | Benardrick McKinney | HOU | LB | at IND |
| 52 | Sam Hubbard | CIN | DE | vs. JAC |
| 53 | Tyrann Mathieu | KC | S | at DEN |
| 54 | Marcus Davenport | NO | DE | at CHI |
| 55 | Janoris Jenkins | NYG | CB | vs. ARI |
| 56 | Neville Hewitt | NYJ | LB | vs. NE |
| 57 | Kwon Alexander | SF | LB | at WAS |
| 58 | Khalil Mack | CHI | LB | vs. NO |
| 59 | Brandon Graham | PHI | DE | at DAL |
| 60 | Danny Trevathan | CHI | LB | vs. NO |
| 61 | Jerome Baker | MIA | LB | at BUF |
| 62 | Grady Jarrett | ATL | DT | vs. LAR |
| 63 | Jessie Bates III | CIN | S | vs. JAC |
| 64 | Kyle Fuller | CHI | CB | vs. NO |
| 65 | Hasean Clinton-Dix | CHI | S | vs. NO |
| 66 | Thomas Davis | LAC | LB | at TEN |
| 67 | Alec Ogletree | NYG | LB | vs. ARI |
| 68 | Logan Ryan | TEN | CB | vs. LAC |
| 69 | Jarrad Davis | DET | LB | vs. MIN |
| 70 | Clayton Geathers | IND | S | vs. HOU |
