| Rank | Player | Team | Pos | Opp |
| 1 | Darius Leonard | IND | LB | at PIT |
| 2 | Joey Bosa | LAC | DE | vs. GB |
| 3 | Jordan Hicks | ARI | LB | vs. SF |
| 4 | Danielle Hunter | MIN | DE | at KC |
| 5 | Landon Collins | WAS | S | at BUF |
| 6 | Luke Kuechly | CAR | LB | vs. TEN |
| 7 | Bobby Wagner | SEA | LB | vs. TB |
| 8 | Blake Martinez | GB | LB | at LAC |
| 9 | Joe Schobert | CLE | LB | at DEN |
| 10 | Tracy Walker | DET | S | at OAK |
| 11 | Jamal Adams | NYJ | S | at MIA |
| 12 | Myles Garrett | CLE | DE | at DEN |
| 13 | Jordan Poyer | BUF | S | vs. WAS |
| 14 | Harrison Smith | MIN | S | at KC |
| 15 | Jamie Collins | NE | LB | at BAL |
| 16 | Eric Kendricks | MIN | LB | at KC |
| 17 | Kevin Byard | TEN | S | at CAR |
| 18 | Devin Bush | PIT | LB | vs. IND |
| 19 | Danny Trevathan | CHI | LB | at PHI |
| 20 | Budda Baker | ARI | S | vs. SF |
| 21 | Nick Bosa | SF | DE | at ARI |
| 22 | Zach Cunningham | HOU | LB | at JAC |
| 23 | Jabrill Peppers | NYG | S | vs. DAL |
| 24 | Roquan Smith | CHI | LB | at PHI |
| 25 | Logan Ryan | TEN | CB | at CAR |
| 26 | Ronnie Harrison | JAC | S | vs. HOU |
| 27 | Rashaan Evans | TEN | LB | at CAR |
| 28 | Shaq Thompson | CAR | LB | vs. TEN |
| 29 | DeForest Buckner | SF | DT | at ARI |
| 30 | Calais Campbell | JAC | DE | vs. HOU |
| 31 | Khalil Mack | CHI | LB | at PHI |
| 32 | Alec Ogletree | NYG | LB | vs. DAL |
| 33 | K.J. Wright | SEA | LB | vs. TB |
| 34 | Tremaine Edmunds | BUF | LB | vs. WAS |
| 35 | Justin Houston | IND | DE | at PIT |
| 36 | Kwon Alexander | SF | LB | at ARI |
| 37 | Devin White | TB | LB | at SEA |
| 38 | Antoine Bethea | NYG | S | vs. DAL |
| 39 | Todd Davis | DEN | LB | vs. CLE |
| 40 | Lavonte David | TB | LB | at SEA |
| 41 | Eric Reid | CAR | S | vs. TEN |
| 42 | Cameron Heyward | PIT | DE | vs. IND |
| 43 | Benardrick McKinney | HOU | LB | at JAC |
| 44 | Haason Reddick | ARI | LB | vs. SF |
| 45 | Tyrann Mathieu | KC | S | vs. MIN |
| 46 | Everson Griffen | MIN | DE | at KC |
| 47 | Shaquil Barrett | TB | LB | at SEA |
| 48 | Fred Warner | SF | LB | at ARI |
| 49 | Minkah Fitzpatrick | PIT | S | vs. IND |
| 50 | Yannick Ngakoue | JAC | DE | vs. HOU |
