| Rank | Running Backs | Team | Opp |
| 1 | Ezekiel Elliott | DAL | at NO |
| 2 | Christian McCaffrey | CAR | at HOU |
| 3 | Alvin Kamara | NO | vs. DAL |
| 4 | Austin Ekeler | LAC | at MIA |
| 5 | Derrick Henry | TEN | at ATL |
| 6 | Dalvin Cook | MIN | at CHI |
| 7 | Marlon Mack | IND | vs. OAK |
| 8 | David Johnson | ARI | vs. SEA |
| 9 | Mark Ingram | BAL | vs. CLE |
| 10 | Chris Carson | SEA | at ARI |
| 11 | Nick Chubb | CLE | at BAL |
| 12 | Todd Gurley | LAR | vs. TB |
| 13 | Leonard Fournette | JAC | at DEN |
| 14 | Aaron Jones | GB | vs. PHI |
| 15 | Kerryon Johnson | DET | vs. KC |
| 16 | James Conner | PIT | vs. CIN |
| 17 | Joe Mixon | CIN | at PIT |
| 18 | Phillip Lindsay | DEN | vs. JAC |
| 19 | Josh Jacobs | OAK | at IND |
| 20 | Sony Michel | NE | at BUF |
| 21 | Devonta Freeman | ATL | vs. TEN |
| 22 | David Montgomery | CHI | vs. MIN |
| 23 | LeSean McCoy | KC | at DET |
| 24 | Carlos Hyde | HOU | vs. CAR |
| 25 | Royce Freeman | DEN | vs. JAC |
| 26 | Miles Sanders | PHI | at GB |
| 27 | Wayne Gallman | NYG | vs. WAS |
| 28 | Frank Gore | BUF | vs. NE |
| 29 | Justin Jackson | LAC | at MIA |
| 30 | James White | NE | at BUF |
| 31 | Adrian Peterson | WAS | at NYG |
| 32 | Duke Johnson | HOU | vs. CAR |
| 33 | Chris Thompson | WAS | at NYG |
| 34 | Peyton Barber | TB | at LAR |
| 35 | Kenyan Drake | MIA | vs. LAC |
| 36 | Malcolm Brown | LAR | vs. TB |
| 37 | Ronald Jones II | TB | at LAR |
| 38 | Rex Burkhead | NE | at BUF |
| 39 | Jordan Howard | PHI | at GB |
| 40 | Darrel Williams | KC | at DET |
| 41 | Rashaad Penny | SEA | at ARI |
| 42 | Tarik Cohen | CHI | vs. MIN |
| 43 | Latavius Murray | NO | vs. DAL |
| 44 | Jamaal Williams | GB | vs. PHI |
| 45 | Gus Edwards | BAL | vs. CLE |
| 46 | Ito Smith | ATL | vs. TEN |
| 47 | Tony Pollard | DAL | at NO |
| 48 | Kalen Ballage | MIA | vs. LAC |
| 49 | Jaylen Samuels | PIT | vs. CIN |
| 50 | Giovani Bernard | CIN | at PIT |
