| Rank | Running Backs | Team | Opp |
| 1 | Dalvin Cook | MIN | at NYG |
| 2 | Christian McCaffrey | CAR | vs. JAC |
| 3 | Ezekiel Elliott | DAL | vs. GB |
| 4 | Nick Chubb | CLE | at SF |
| 5 | Alvin Kamara | NO | vs. TB |
| 6 | David Johnson | ARI | at CIN |
| 7 | Chris Carson | SEA | vs. LAR |
| 8 | Leonard Fournette | JAC | at CAR |
| 9 | Joe Mixon | CIN | vs. ARI |
| 10 | Derrick Henry | TEN | vs. BUF |
| 11 | Le'Veon Bell | NYJ | at PHI |
| 12 | Aaron Jones | GB | at DAL |
| 13 | Todd Gurley | LAR | at SEA |
| 14 | Austin Ekeler | LAC | vs. DEN |
| 15 | Marlon Mack | IND | at KC |
| 16 | James Conner | PIT | vs. BAL |
| 17 | David Montgomery | CHI | at OAK |
| 18 | Mark Ingram | BAL | at PIT |
| 19 | LeSean McCoy | KC | vs. IND |
| 20 | Wayne Gallman | NYG | vs. MIN |
| 21 | Phillip Lindsay | DEN | at LAC |
| 22 | Devonta Freeman | ATL | at HOU |
| 23 | Josh Jacobs | OAK | vs. CHI |
| 24 | Melvin Gordon | LAC | vs. DEN |
| 25 | Sony Michel | NE | at WAS |
| 26 | Royce Freeman | DEN | at LAC |
| 27 | Jordan Howard | PHI | vs. NYJ |
| 28 | Carlos Hyde | HOU | vs. ATL |
| 29 | Matt Breida | SF | vs. CLE |
| 30 | Miles Sanders | PHI | vs. NYJ |
| 31 | James White | NE | at WAS |
| 32 | Frank Gore | BUF | at TEN |
| 33 | Tarik Cohen | CHI | at OAK |
| 34 | Darrel Williams | KC | vs. IND |
| 35 | Ronald Jones II | TB | at NO |
| 36 | Jaylen Samuels | PIT | vs. BAL |
| 37 | Chris Thompson | WAS | vs. NE |
| 38 | Duke Johnson | HOU | vs. ATL |
| 39 | Adrian Peterson | WAS | vs. NE |
| 40 | Rex Burkhead | NE | at WAS |
| 41 | Rashaad Penny | SEA | vs. LAR |
| 42 | Peyton Barber | TB | at NO |
| 43 | Gus Edwards | BAL | at PIT |
| 44 | Devin Singletary | BUF | at TEN |
| 45 | Ito Smith | ATL | at HOU |
| 46 | Malcolm Brown | LAR | at SEA |
| 47 | Raheem Mostert | SF | vs. CLE |
| 48 | Tevin Coleman | SF | vs. CLE |
| 49 | Giovani Bernard | CIN | vs. ARI |
| 50 | Latavius Murray | NO | vs. TB |
| 51 | Nyheim Hines | IND | at KC |
| 52 | Damien Williams | KC | vs. IND |
| 53 | Tony Pollard | DAL | vs. GB |
| 54 | Alexander Mattison | MIN | at NYG |
| 55 | Jeff Wilson | SF | vs. CLE |
| 56 | Jordan Wilkins | IND | at KC |
| 57 | Dion Lewis | TEN | vs. BUF |
| 58 | Justice Hill | BAL | at PIT |
| 59 | Chase Edmonds | ARI | at CIN |
| 60 | C.J. Prosise | SEA | vs. LAR |
| 61 | Dare Ogunbowale | TB | at NO |
| 62 | T.J. Yeldon | BUF | at TEN |
| 63 | Darren Sproles | PHI | vs. NYJ |
| 64 | Jonathan Hilliman | NYG | vs. MIN |
| 65 | Jalen Richard | OAK | vs. CHI |
