| Rank | Running Backs | Team | Opp |
| 1 | Christian McCaffrey | CAR | at TB |
| 2 | Dalvin Cook | MIN | vs. PHI |
| 3 | Ezekiel Elliott | DAL | at NYJ |
| 4 | Alvin Kamara | NO | at JAC |
| 5 | Aaron Jones | GB | vs. DET |
| 6 | Chris Carson | SEA | at CLE |
| 7 | Nick Chubb | CLE | vs. SEA |
| 8 | Leonard Fournette | JAC | vs. NO |
| 9 | Mark Ingram | BAL | vs. CIN |
| 10 | David Johnson | ARI | vs. ATL |
| 11 | Todd Gurley | LAR | vs. SF |
| 12 | Derrick Henry | TEN | at DEN |
| 13 | Le'Veon Bell | NYJ | vs. DAL |
| 14 | James Conner | PIT | at LAC |
| 15 | Sony Michel | NE | vs. NYG |
| 16 | Phillip Lindsay | DEN | vs. TEN |
| 17 | Kerryon Johnson | DET | at GB |
| 18 | Joe Mixon | CIN | at BAL |
| 19 | Austin Ekeler | LAC | vs. PIT |
| 20 | Melvin Gordon | LAC | vs. PIT |
| 21 | Devonta Freeman | ATL | at ARI |
| 22 | James White | NE | vs. NYG |
| 23 | Matt Breida | SF | at LAR |
| 24 | Jordan Howard | PHI | at MIN |
| 25 | Damien Williams | KC | vs. HOU |
| 26 | Tevin Coleman | SF | at LAR |
| 27 | Royce Freeman | DEN | vs. TEN |
| 28 | Jonathan Hilliman | NYG | at NE |
| 29 | Carlos Hyde | HOU | at KC |
| 30 | Ronald Jones II | TB | vs. CAR |
| 31 | Kenyan Drake | MIA | vs. WAS |
| 32 | LeSean McCoy | KC | vs. HOU |
| 33 | Adrian Peterson | WAS | at MIA |
| 34 | Chris Thompson | WAS | at MIA |
| 35 | Miles Sanders | PHI | at MIN |
| 36 | Peyton Barber | TB | vs. CAR |
| 37 | Duke Johnson | HOU | at KC |
| 38 | Gus Edwards | BAL | vs. CIN |
| 39 | Ito Smith | ATL | at ARI |
| 40 | Rashaad Penny | SEA | at CLE |
| 41 | Latavius Murray | NO | at JAC |
| 42 | Malcolm Brown | LAR | vs. SF |
| 43 | Chase Edmonds | ARI | vs. ATL |
| 44 | Raheem Mostert | SF | at LAR |
| 45 | Alexander Mattison | MIN | vs. PHI |
| 46 | Giovani Bernard | CIN | at BAL |
| 47 | Tony Pollard | DAL | at NYJ |
| 48 | Brandon Bolden | NE | vs. NYG |
| 49 | Dion Lewis | TEN | at DEN |
| 50 | Darrel Williams | KC | vs. HOU |
