| Rank | Running Backs | Team | Opp |
| 1 | Dalvin Cook | MIN | vs. WAS |
| 2 | Christian McCaffrey | CAR | at SF |
| 3 | James Conner | PIT | vs. MIA |
| 4 | Leonard Fournette | JAC | vs. NYJ |
| 5 | Saquon Barkley | NYG | at DET |
| 6 | Chris Carson | SEA | at ATL |
| 7 | Todd Gurley | LAR | vs. CIN |
| 8 | Aaron Jones | GB | at KC |
| 9 | Derrick Henry | TEN | vs. TB |
| 10 | Le'Veon Bell | NYJ | at JAC |
| 11 | Nick Chubb | CLE | at NE |
| 12 | Sony Michel | NE | vs. CLE |
| 13 | Marlon Mack | IND | vs. DEN |
| 14 | Josh Jacobs | OAK | at HOU |
| 15 | Latavius Murray | NO | vs. ARI |
| 16 | Devonta Freeman | ATL | vs. SEA |
| 17 | Phillip Lindsay | DEN | at IND |
| 18 | Tevin Coleman | SF | vs. CAR |
| 19 | Ty Johnson | DET | vs. NYG |
| 20 | Melvin Gordon | LAC | at CHI |
| 21 | Austin Ekeler | LAC | at CHI |
| 22 | Chase Edmonds | ARI | at NO |
| 23 | Royce Freeman | DEN | at IND |
| 24 | David Montgomery | CHI | vs. LAC |
| 25 | Carlos Hyde | HOU | vs. OAK |
| 26 | LeSean McCoy | KC | vs. GB |
| 27 | James White | NE | vs. CLE |
| 28 | Jordan Howard | PHI | at BUF |
| 29 | Jamaal Williams | GB | at KC |
| 30 | Matt Breida | SF | vs. CAR |
| 31 | Joe Mixon | CIN | at LAR |
| 32 | Miles Sanders | PHI | at BUF |
| 33 | Frank Gore | BUF | vs. PHI |
| 34 | Adrian Peterson | WAS | at MIN |
| 35 | Tarik Cohen | CHI | vs. LAC |
| 36 | Damien Williams | KC | vs. GB |
| 37 | J.D. McKissic | DET | vs. NYG |
| 38 | Kenyan Drake | MIA | at PIT |
| 39 | Ronald Jones II | TB | at TEN |
| 40 | Devin Singletary | BUF | vs. PHI |
| 41 | Darrell Henderson | LAR | vs. CIN |
| 42 | Duke Johnson | HOU | vs. OAK |
| 43 | Mark Walton | MIA | at PIT |
| 44 | Alexander Mattison | MIN | vs. WAS |
| 45 | Peyton Barber | TB | at TEN |
| 46 | Benny Snell Jr. | PIT | vs. MIA |
| 47 | Wendell Smallwood | WAS | at MIN |
| 48 | Alvin Kamara | NO | vs. ARI |
| 49 | Brandon Bolden | NE | vs. CLE |
| 50 | Brian Hill | ATL | vs. SEA |
