| Rank | Running Backs | Team | Opp |
| 1 | Chris Carson | SEA | at CAR |
| 2 | Derrick Henry | TEN | vs. HOU |
| 3 | Christian McCaffrey | CAR | vs. SEA |
| 4 | Dalvin Cook | MIN | at LAC |
| 5 | Leonard Fournette | JAC | at OAK |
| 6 | Ezekiel Elliott | DAL | vs. LAR |
| 7 | Saquon Barkley | NYG | vs. MIA |
| 8 | Nick Chubb | CLE | at ARI |
| 9 | Aaron Jones | GB | vs. CHI |
| 10 | Todd Gurley | LAR | at DAL |
| 11 | Alvin Kamara | NO | vs. IND |
| 12 | Mark Ingram | BAL | vs. NYJ |
| 13 | Melvin Gordon | LAC | vs. MIN |
| 14 | Phillip Lindsay | DEN | at KC |
| 15 | Miles Sanders | PHI | at WAS |
| 16 | Austin Ekeler | LAC | vs. MIN |
| 17 | Joe Mixon | CIN | vs. NE |
| 18 | Raheem Mostert | SF | vs. ATL |
| 19 | David Montgomery | CHI | at GB |
| 20 | Devin Singletary | BUF | at PIT |
| 21 | Kareem Hunt | CLE | at ARI |
| 22 | Kenyan Drake | ARI | vs. CLE |
| 23 | Le'Veon Bell | NYJ | at BAL |
| 24 | Sony Michel | NE | at CIN |
| 25 | Adrian Peterson | WAS | vs. PHI |
| 26 | Marlon Mack | IND | at NO |
| 27 | James White | NE | at CIN |
| 28 | Devonta Freeman | ATL | at SF |
| 29 | Patrick Laird | MIA | at NYG |
| 30 | Ronald Jones II | TB | at DET |
| 31 | LeSean McCoy | KC | vs. DEN |
| 32 | Bo Scarbrough | DET | vs. TB |
| 33 | Carlos Hyde | HOU | at TEN |
| 34 | Josh Jacobs | OAK | vs. JAC |
| 35 | DeAndre Washington | OAK | vs. JAC |
| 36 | Jamaal Williams | GB | vs. CHI |
| 37 | Duke Johnson | HOU | at TEN |
| 38 | Latavius Murray | NO | vs. IND |
| 39 | Benny Snell Jr. | PIT | vs. BUF |
| 40 | Royce Freeman | DEN | at KC |
| 41 | Matt Breida | SF | vs. ATL |
| 42 | Alexander Mattison | MIN | at LAC |
| 43 | Tarik Cohen | CHI | at GB |
| 44 | Darwin Thompson | KC | vs. DEN |
| 45 | Gus Edwards | BAL | vs. NYJ |
| 46 | Peyton Barber | TB | at DET |
| 47 | Boston Scott | PHI | at WAS |
| 48 | Tevin Coleman | SF | vs. ATL |
| 49 | David Johnson | ARI | vs. CLE |
| 50 | Jaylen Samuels | PIT | vs. BUF |
| 51 | Malcolm Brown | LAR | at DAL |
| 52 | Chris Thompson | WAS | vs. PHI |
| 53 | Nyheim Hines | IND | at NO |
| 54 | Jalen Richard | OAK | vs. JAC |
| 55 | Rex Burkhead | NE | at CIN |
| 56 | Frank Gore | BUF | at PIT |
| 57 | James Conner | PIT | vs. BUF |
| 58 | J.D. McKissic | DET | vs. TB |
| 59 | Myles Gaskin | MIA | at NYG |
| 60 | Brian Hill | ATL | at SF |
| 61 | Ty Johnson | DET | vs. TB |
| 62 | Dare Ogunbowale | TB | at DET |
| 63 | Giovani Bernard | CIN | vs. NE |
| 64 | Dion Lewis | TEN | vs. HOU |
| 65 | Ryquell Armstead | JAC | at OAK |
| 66 | Ty Montgomery | NYJ | at BAL |
| 67 | Spencer Ware | KC | vs. DEN |
| 68 | Jay Ajayi | PHI | at WAS |
| 69 | Chase Edmonds | ARI | vs. CLE |
| 70 | Jordan Wilkins | IND | at NO |
