Keep your eye on Dalvin Cook. If he doesn't play, which I think he won't, look for Mike Boone to help you fill your flex spot. Other than that use these rankings and bring home the bacon. Good luck and congratulations for making to the fantasy football week 16 championship.
| Rank | Running Backs | Team | Opp |
| 1 | Chris Carson | SEA | vs. ARI |
| 2 | Christian McCaffrey | CAR | at IND |
| 3 | Ezekiel Elliott | DAL | at PHI |
| 4 | Saquon Barkley | NYG | at WAS |
| 5 | Derrick Henry | TEN | vs. NO |
| 6 | Joe Mixon | CIN | at MIA |
| 7 | Leonard Fournette | JAC | at ATL |
| 8 | Nick Chubb | CLE | vs. BAL |
| 9 | Alvin Kamara | NO | at TEN |
| 10 | Mark Ingram | BAL | at CLE |
| 11 | Melvin Gordon | LAC | vs. OAK |
| 12 | Aaron Jones | GB | at MIN |
| 13 | Marlon Mack | IND | vs. CAR |
| 14 | Miles Sanders | PHI | vs. DAL |
| 15 | Todd Gurley | LAR | at SF |
| 16 | Devonta Freeman | ATL | vs. JAC |
| 17 | Austin Ekeler | LAC | vs. OAK |
| 18 | James Conner | PIT | at NYJ |
| 19 | Phillip Lindsay | DEN | vs. DET |
| 20 | Kenyan Drake | ARI | at SEA |
| 21 | Raheem Mostert | SF | vs. LAR |
| 22 | David Montgomery | CHI | vs. KC |
| 23 | Le'Veon Bell | NYJ | vs. PIT |
| 24 | Devin Singletary | BUF | at NE |
| 25 | Adrian Peterson | WAS | vs. NYG |
| 26 | DeAndre Washington | OAK | at LAC |
| 27 | Mike Boone | MIN | vs. GB |
| 28 | Kareem Hunt | CLE | vs. BAL |
| 29 | Sony Michel | NE | vs. BUF |
| 30 | Patrick Laird | MIA | vs. CIN |
| 31 | Boston Scott | PHI | vs. DAL |
| 32 | Carlos Hyde | HOU | at TB |
| 33 | Ronald Jones II | TB | vs. HOU |
| 34 | James White | NE | vs. BUF |
| 35 | Royce Freeman | DEN | vs. DET |
| 36 | Latavius Murray | NO | at TEN |
| 37 | Tarik Cohen | CHI | vs. KC |
| 38 | Jamaal Williams | GB | at MIN |
| 39 | Peyton Barber | TB | vs. HOU |
| 40 | Duke Johnson | HOU | at TB |
