Sitting atop our week 16 team defense rankings is the Kansas City Chiefs. But that probably isn't helping you win your fantasy league in week 16 unless of course, you have the Chiefs team defense. Nevertheless, there's some other teams ranked below that are likely on your waiver wire that you should play if your existing team defense is matched up against a power house like New England or New Orleans. If you're like me you've already secured your playoff / Superbowl defense. If not, I hope these rankings help you win your fantasy league! Goof luck this week!
| Rank | Team DST | Opp |
| 1 | Kansas City Chiefs | vs. CLE |
| 2 | Seattle Seahawks | vs. STL |
| 3 | Carolina Panthers | at ATL |
| 4 | Denver Broncos | vs. CIN |
| 5 | Houston Texans | at TEN |
| 6 | New England Patriots | at NYJ |
| 7 | Cincinnati Bengals | at DEN |
| 8 | Buffalo Bills | vs. DAL |
| 9 | Detroit Lions | vs. SF |
| 10 | Arizona Cardinals | vs. GB |
| 11 | Tampa Bay Buccaneers | vs. CHI |
| 12 | Chicago Bears | at TB |
| 13 | Minnesota Vikings | vs. NYG |
| 14 | Miami Dolphins | vs. IND |
| 15 | Washington Redskins | at PHI |
| 16 | Green Bay Packers | at ARI |
| 17 | St. Louis Rams | at SEA |
| 18 | Oakland Raiders | vs. SD |
| 19 | New York Giants | at MIN |
| 20 | Pittsburgh Steelers | at BAL |
| 21 | Tennessee Titans | vs. HOU |
| 22 | Dallas Cowboys | at BUF |
| 23 | Philadelphia Eagles | vs. WAS |
| 24 | Indianapolis Colts | at MIA |
| 25 | San Francisco 49ers | at DET |
| 26 | Cleveland Browns | at KC |
| 27 | Jacksonville Jaguars | at NO |
| 28 | New Orleans Saints | vs. JAC |
| 29 | New York Jets | vs. NE |
| 30 | Atlanta Falcons | vs. CAR |
| 31 | San Diego Chargers | at OAK |
| 32 | Baltimore Ravens | vs. PIT |
