| Rank | Running Backs | Team | Opp |
| 1 | Saquon Barkley | NYG | vs. DAL |
| 2 | Melvin Gordon | LAC | at DEN |
| 3 | Derrick Henry | TEN | vs. IND |
| 4 | Chris Carson | SEA | vs. ARI |
| 5 | Joe Mixon | CIN | at PIT |
| 6 | Sony Michel | NE | vs. NYJ |
| 7 | Dalvin Cook | MIN | vs. CHI |
| 8 | Jamaal Williams | GB | vs. DET |
| 9 | Nick Chubb | CLE | at BAL |
| 10 | Damien Williams | KC | vs. OAK |
| 11 | Marlon Mack | IND | at TEN |
| 12 | C.J. Anderson | LAR | vs. SF |
| 13 | Gus Edwards | BAL | vs. CLE |
| 14 | David Johnson | ARI | at SEA |
| 15 | Elijah McGuire | NYJ | at NE |
| 16 | Jeff Wilson | SF | at LAR |
| 17 | Adrian Peterson | WAS | vs. PHI |
| 18 | Royce Freeman | DEN | vs. LAC |
| 19 | Peyton Barber | TB | vs. ATL |
| 20 | Leonard Fournette | JAC | at HOU |
| 21 | Jaylen Samuels | PIT | vs. CIN |
| 22 | Tarik Cohen | CHI | at MIN |
| 23 | Doug Martin | OAK | at KC |
| 24 | James White | NE | vs. NYJ |
| 25 | Christian McCaffrey | CAR | at NO |
| 26 | Jordan Howard | CHI | at MIN |
| 27 | Josh Adams | PHI | at WAS |
| 28 | Ezekiel Elliott | DAL | at NYG |
| 29 | LeSean McCoy | BUF | vs. MIA |
| 30 | Kenyan Drake | MIA | at BUF |
| 31 | Brian Hill | ATL | at TB |
| 32 | James Conner | PIT | vs. CIN |
| 33 | Kenneth Dixon | BAL | vs. CLE |
| 34 | Kalen Ballage | MIA | at BUF |
| 35 | Darren Sproles | PHI | at WAS |
| 36 | Zach Zenner | DET | at GB |
| 37 | Dion Lewis | TEN | vs. IND |
| 38 | Jalen Richard | OAK | at KC |
| 39 | Lamar Miller | HOU | vs. JAC |
| 40 | Mike Davis | SEA | vs. ARI |
| 41 | Alfred Blue | HOU | vs. JAC |
| 42 | Nyheim Hines | IND | at TEN |
| 43 | Theo Riddick | DET | at GB |
| 44 | John Kelly | LAR | vs. SF |
| 45 | Alvin Kamara | NO | vs. CAR |
| 46 | Justin Jackson | LAC | at DEN |
| 47 | Latavius Murray | MIN | vs. CHI |
| 48 | Austin Ekeler | LAC | at DEN |
| 49 | Spencer Ware | KC | vs. OAK |
| 50 | Wendell Smallwood | PHI | at WAS |
| 51 | Duke Johnson | CLE | at BAL |
| 52 | LeGarrette Blount | DET | at GB |
| 53 | Tevin Coleman | ATL | at TB |
| 54 | Rashaad Penny | SEA | vs. ARI |
| 55 | Rod Smith | DAL | at NYG |
| 56 | Rex Burkhead | NE | vs. NYJ |
| 57 | Chris Thompson | WAS | vs. PHI |
| 58 | Jacquizz Rodgers | TB | vs. ATL |
| 59 | Mark Ingram | NO | vs. CAR |
| 60 | Devontae Booker | DEN | vs. LAC |
| 61 | Chase Edmonds | ARI | at SEA |
| 62 | D'Onta Foreman | HOU | vs. JAC |
| 63 | Cameron Artis-Payne | CAR | at NO |
| 64 | Dwayne Washington | NO | vs. CAR |
| 65 | Trenton Cannon | NYJ | at NE |
| 66 | Giovani Bernard | CIN | at PIT |
| 67 | Carlos Hyde | JAC | at HOU |
| 68 | Keith Ford | BUF | vs. MIA |
| 69 | Ronald Jones II | TB | vs. ATL |
| 70 | Stevan Ridley | PIT | vs. CIN |
| 71 | Charcandrick West | KC | vs. OAK |
| 72 | T.J. Yeldon | JAC | at HOU |
| 73 | Todd Gurley | LAR | vs. SF |
| 74 | Darrel Williams | KC | vs. OAK |
| 75 | Alfred Morris | SF | at LAR |
| 76 | Jordan Wilkins | IND | at TEN |
| 77 | Wayne Gallman | NYG | vs. DAL |
| 78 | Kyle Juszczyk | SF | at LAR |
| 79 | Brandon Bolden | MIA | at BUF |
| 80 | Kapri Bibbs | GB | vs. DET |
