| Rank | Running Backs | Team | Opp |
| 1 | Dalvin Cook | MIN | at KC |
| 2 | Christian McCaffrey | CAR | vs. TEN |
| 3 | Ezekiel Elliott | DAL | at NYG |
| 4 | Saquon Barkley | NYG | vs. DAL |
| 5 | Nick Chubb | CLE | at DEN |
| 6 | Leonard Fournette | JAC | vs. HOU |
| 7 | Aaron Jones | GB | at LAC |
| 8 | Chris Carson | SEA | vs. TB |
| 9 | Josh Jacobs | OAK | vs. DET |
| 10 | Derrick Henry | TEN | at CAR |
| 11 | Tevin Coleman | SF | at ARI |
| 12 | Le'Veon Bell | NYJ | at MIA |
| 13 | Marlon Mack | IND | at PIT |
| 14 | Sony Michel | NE | at BAL |
| 15 | Phillip Lindsay | DEN | vs. CLE |
| 16 | Melvin Gordon | LAC | vs. GB |
| 17 | Royce Freeman | DEN | vs. CLE |
| 18 | Jordan Howard | PHI | vs. CHI |
| 19 | Austin Ekeler | LAC | vs. GB |
| 20 | Mark Ingram | BAL | vs. NE |
| 21 | David Montgomery | CHI | at PHI |
| 22 | Carlos Hyde | HOU | at JAC |
| 23 | Adrian Peterson | WAS | at BUF |
| 24 | Mark Walton | MIA | vs. NYJ |
| 25 | Jamaal Williams | GB | at LAC |
| 26 | LeSean McCoy | KC | vs. MIN |
| 27 | Devin Singletary | BUF | vs. WAS |
| 28 | Frank Gore | BUF | vs. WAS |
| 29 | James White | NE | at BAL |
| 30 | Kenyan Drake | ARI | vs. SF |
| 31 | Jaylen Samuels | PIT | vs. IND |
| 32 | Ronald Jones II | TB | at SEA |
| 33 | Miles Sanders | PHI | vs. CHI |
| 34 | James Conner | PIT | vs. IND |
| 35 | Duke Johnson | HOU | at JAC |
| 36 | Ty Johnson | DET | at OAK |
| 37 | Damien Williams | KC | vs. MIN |
| 38 | Tra Carson | DET | at OAK |
| 39 | Peyton Barber | TB | at SEA |
| 40 | Raheem Mostert | SF | at ARI |
| 41 | Alexander Mattison | MIN | at KC |
| 42 | Gus Edwards | BAL | vs. NE |
| 43 | Rashaad Penny | SEA | vs. TB |
| 44 | J.D. McKissic | DET | at OAK |
| 45 | DeAndre Washington | OAK | vs. DET |
| 46 | Kalen Ballage | MIA | vs. NYJ |
| 47 | Nyheim Hines | IND | at PIT |
| 48 | Wendell Smallwood | WAS | at BUF |
| 49 | Tarik Cohen | CHI | at PHI |
| 50 | Zach Zenner | ARI | vs. SF |
| 51 | Rex Burkhead | NE | at BAL |
| 52 | Tony Pollard | DAL | at NYG |
| 53 | Boston Scott | PHI | vs. CHI |
| 54 | Dion Lewis | TEN | at CAR |
| 55 | Dare Ogunbowale | TB | at SEA |
| 56 | Jordan Wilkins | IND | at PIT |
| 57 | Jalen Richard | OAK | vs. DET |
| 58 | Matt Breida | SF | at ARI |
| 59 | Darrel Williams | KC | vs. MIN |
| 60 | Brandon Bolden | NE | at BAL |
